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It is estimated that worldwide there are more than 150 million ED patients, with the global population aging, the number of ED patients will continue to increase. WHO recommended choice for first-line treatment of  ED is phosphodiesterase 5 (PDE5) inhibitors.

Currently, PDE5 inhibitors have been listed are those three kinds, namely Pfizer's Viagra, Eli Lilly's Cialis and Bayer's Levitra.

But the Viagra is the originator of ED areas,its sales performance has been satisfactory, while Cialis with lasting effect and good safety etc.,recognized by male and  urologist, Levitra as a rising star is also popular in the industry, but Bayer has been steady about the layout of the market, the current global market share gap far compared with Viagra and Cialis , therefore, the top spot in ED market is in fact  the PK war between Viagra and Cialis. 

In 1998, after Viagra listing in the United States market has been occupying the top spot in the ED treatment drug field , sales have been steadily rising,the highest peak is in 2012,when the global sales is $ 2.051 billion.

Cialis was approved in 2002, listed in France market in 2003. Though the initial results is not so high as Viagra, but in 2007, its growth rate became rapid, its 2013 global sales is more than Viagra, reaching to $ 2.159 billion. 


Efficacy and side effects of viagra cialis erectile dysfunction pillsAccording to the duration of drug effects, PDE5 inhibitors are divided into short-acting and long-acting two kinds.

Viagra (sildenafil) belongs to the short-acting drug, the duration of action is 4 to 5 hours; it can not be mixed use with nitrates,otherwise  it may cause low blood pressure; when taking this medication can not drink alcohol, or will reduce their effectiveness. Clinically proven Viagra has some short-acting side effects, including headache, vertigo, fainting, cover cardiovascular disease, lower blood pressure, glaucoma, temporary deafness and aggravate sleep apnea.

Cialis (tadalafil) belongs to the long-acting drugs, reaction time is 36 hours; it is different from Viagra, alcohol and high-fat diet without influence; and safety is better compared with Viagra, fewer adverse reactions after taking the drug,since its on the market, do not find its formation in vivo drug residues.


Indications: The main ingredients in Viagra is sildenafil citrate, was originally developed by Pfizer as a treatment of angina drug,in clinical trials found its treatment of angina effect is in general, but there are special effects for the treatment of impotence, manufacturers were declared on medication to treat impotence . The latest study found that sildenafil citrate therapy can also be used to treat primary dysmenorrhea and intrauterine growth restriction (IGR).

Cialis tadalafil major component, in addition to for the treatment of erectile dysfunction, but also for the treatment of pulmonary arterial hypertension. New research shows that it also has a cardioprotective effect of preventing sustained fatal ischemic injury.

Data show that the Pfizer Company, 2013 total annual revenues is $ 51.584 billion, R & D expenses is $ 6.678 billion, the company has 10 global sales of over $ 1 billion high-quality products, including Lyrica, Pei children series, Enbrel, Celebrex, Lipitor, Viagra, etc., and Viagra last year worldwide sales amounted to $ 1.881 billion, only 3.6% of total revenue.
The Eli Lilly's company,2013 the total annual revenues is $ 23.113 billion, less than half of Pfizer's,research and development costs is $ 5.531 billion, the company's global sales of over $ 1 billion products has 8 kinds, including Cymbalta, Alimta, Humalog, Cialis, etc. last year, worldwide sales of Cialis was $ 2.159 billion, 9.3% of total revenue.
Layout in China. in the 1980s, Pfizer enter the Chinese market, has founded  Dalian Pfizer Pharmaceuticals, Pfizer Suzhou Pharmaceuticals  and Wuxi Pfizer Pharmaceuticals in china, in 2012 founded Hisun Pfizer Pharmaceutical Co., Ltd. Pfizer has invested nearly $ 1 billion in China, business operations spread more than 300 cities in China, including the listing of prescription drugs, vaccines and health drugs.
In 1918, Eli Lilly Company opened its first overseas office in Shanghai, which took the first step of globalization, in 1993 established  Eli Lilly Asia representative Shanghai office, Lilly has invested more than  $ 300 million in China,so far in the country set up one factory, 30 offices, and a research and development base in Zhangjiang, conduct synthesized chemical research.

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