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Eating Viagra,how long of the viagra effects last ?   

Viagra is a medicament for the treatment of erectile dysfunction,when patients taking Viagra, concern is the efficacy of the drug, in fact, Viagra tolerance is relatively good, the patient at the time of medication, be sure to pay attention to medication method, so that the viagra can play a pharmacodynamics.

After Eating Viagra,how long of the effects?

After taking Viagra, the effects is well, Viagra is primarily by metabolism of cytochrome P4503A4 (major route) and 2C9 (minor route), so these isoenzyme inhibitors reduce sildenafil clearance.

In vivo: healthy volunteers while taking Viagra 50mg and cimetidine (a non-specific cytochrome P450 inhibitor) 800mg, resulting in increased plasma concentrations of sildenafil 56.

For most patients, the recommended initial dose of 50mg,taking in about 1 hour before sexual activity ; but any time before sexual activity within 0.5 to 4 hours can be taken.

Based on the efficacy and tolerability, the dose can be increased to 100 mg (recommended dose) or decreased to 25 mg. the maximum doses one pills per 1 day.

The following factors is ralated to the plasma levels of sildenafil (AUC) increased : over 65 years of age (by 40), liver damage (eg cirrhosis of the liver, increased by 80), severe renal impairment (creatinine clearance <30ml / min, an increase of 100 ), while taking a potent inhibitor of cytochrome P4503A4 (ketoconazole, itraconazole, an increase of 200), erythromycin increased 182, saquinavir increase 210. 

Since higher plasma levels may also increase the efficacy and incidence of adverse events, so the starting dose in these patients: 25 mg is appropriate. Studies have shown that, HIV protease inhibitors Ritonavir can make sildenafil plasma levels significantly higher (AUC increased 11-fold). For this reason, we recommend that the patients taking Ritonavir, dose every 48 hours no more than 25mg.

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For the treatment of erectile dysfunction and other diseases, patients still have to pay attention to psychological adjustment, which is conducive to the treatment of disease. If you have any questions, you need to consult Viagra information, contact our customer service or send an email to: sex.herb@hotmail.com .

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